Advanced Ghk-Cu Spray

£24.99

GHK-Cu

Gly-His-Lys · Cu²⁺

Cosmetic — Copper Carrier Peptide

GHK-Cu is a naturally occurring copper peptide first isolated from human plasma in 1973. It upregulates over 4,000 human genes, stimulates collagen synthesis, exerts antioxidant effects, and demonstrates broad anti-inflammatory activity.

A well-established topical cosmetic ingredient with growing interest in systemic applications.

Discovery

1973, Loren Pickart

Genes Modulated

>4,000

Key Metal

Copper (Cu²⁺)

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Categories: All Products, Best Sellers, Nasal Spray (peptide)

GHK-Cu

Gly-His-Lys · Cu²⁺

Mechanism of Action

GHK-Cu acts as a biological signal of tissue damage. Plasma levels decline from ~200 ng/mL at age 20 to ~80 ng/mL by age 60.

Gene Expression Modulation

Genome-wide microarray studies identify broad modulation of COL1A1, COL3A1, antioxidant enzymes, and anti-inflammatory pathways, appearing to reset expression toward younger phenotypes.

Copper Transport

Delivers Cu²⁺ to lysyl oxidase (collagen crosslinking) and Cu/Zn superoxide dismutase (antioxidant protection).

Research Dosage Information

Application	Route	Concentration	Notes
Cosmetic anti-aging	Topical	0.1–3% w/v	Well-established safety data
Wound healing (preclinical)	SC	1–50 µg/site	Rodent models
Systemic (exploratory) *	SC injection	1–2 mg/day	Very limited human data

* Exploratory reports: Small number of accounts from aesthetic and biohacking communities. Not peer-reviewed.
* Topical use has established safety data; injectable research is primarily preclinical.