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Ghk-Cu - Cream
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Advanced Ghk-Cu Spray
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GHK-Cu
Gly-His-Lys · Cu²⁺
Cosmetic — Copper Carrier Peptide
GHK-Cu is a naturally occurring copper peptide first isolated from human plasma in 1973. It upregulates over 4,000 human genes, stimulates collagen synthesis, exerts antioxidant effects, and demonstrates broad anti-inflammatory activity.
A well-established topical cosmetic ingredient with growing interest in systemic applications.
Discovery
1973, Loren Pickart
Genes Modulated
>4,000
Key Metal
Copper (Cu²⁺)
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GHK-Cu
Gly-His-Lys · Cu²⁺
Mechanism of Action
GHK-Cu acts as a biological signal of tissue damage. Plasma levels decline from ~200 ng/mL at age 20 to ~80 ng/mL by age 60.
Gene Expression Modulation
Genome-wide microarray studies identify broad modulation of COL1A1, COL3A1, antioxidant enzymes, and anti-inflammatory pathways, appearing to reset expression toward younger phenotypes.
Copper Transport
Delivers Cu²⁺ to lysyl oxidase (collagen crosslinking) and Cu/Zn superoxide dismutase (antioxidant protection).
Research Dosage Information
| Application | Route | Concentration | Notes |
|---|---|---|---|
| Cosmetic anti-aging | Topical | 0.1–3% w/v | Well-established safety data |
| Wound healing (preclinical) | SC | 1–50 µg/site | Rodent models |
| Systemic (exploratory) * | SC injection | 1–2 mg/day | Very limited human data |
* Exploratory reports: Small number of accounts from aesthetic and biohacking communities. Not peer-reviewed.
* Topical use has established safety data; injectable research is primarily preclinical.
| Administration |
Nasal Sprays |
|---|
Vials (Peptides)
Pre-mixed Pens (Peptides)
Nasal Spray (Peptides)
Cream (Peptides)
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