SLU-PP-332
Metabolic — Exercise Mimetic / ERR Agonist
Synthetic ERRα/β/γ pan-agonist · small molecule

SLU-PP-332 is a first-in-class synthetic pan-agonist of the oestrogen-related receptor (ERR) family — ERRα, ERRβ, and ERRγ. Developed at Saint Louis University, it activates the same nuclear receptor transcription factors as aerobic exercise, producing measurable improvements in endurance, fat oxidation, and metabolic health in preclinical models without physical activity. It represents one of the most promising “exercise mimetic” compounds in current research.

Class
ERRα/β/γ pan-agonist — small molecule
Developer
Saint Louis University (Bhatt lab)
Stage
Preclinical — 2023/24 landmark studies