IGF-1 LR3
Price range: £22.99 through £52.99
IGF-1 LR3
Growth Factor — IGF-1 Analogue IGF-1 LR3 is a recombinant analogue of insulin-like growth factor 1 with a modified N-terminus (Arg³ substitution) and 13-amino acid extension that dramatically extends half-life. It is 2–3× more potent than native IGF-1 and does not bind IGF binding proteins, making it significantly more bioavailable. Half-Life: ~20–30 hours (vs 15 min native IGF-1) Potency: 2–3× native IGF-1 IGFBP Binding: Reduced — higher free fraction
IGF-1 LR3
Mechanism of Action
IGF-1 LR3 binds the IGF-1 receptor (IGF1R), activating the PI3K/Akt and MAPK/ERK pathways that drive cell proliferation, protein synthesis, and glucose uptake.
Muscle Protein Synthesis
Activates mTOR signalling independently of the GH axis, stimulating satellite cell proliferation and myofibrillar protein synthesis — making it of significant interest in muscle physiology research.
Anti-apoptotic Effects
IGF1R signalling is a potent suppressor of apoptosis in multiple cell types. This anti-apoptotic activity is relevant to both muscle preservation and — importantly — the oncological safety concerns that limit IGF-1 analogue research in humans.
Research compound only — not licensed for human consumption or therapeutic use. Sold strictly for laboratory research purposes.
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