SLU-PP-332

SLU-PP-332

Mechanism of Action
ERRα, ERRβ, and ERRγ (estrogen-related receptors) are orphan nuclear receptors that function as master regulators of mitochondrial biogenesis, fatty acid oxidation, and oxidative phosphorylation — the same metabolic pathways activated by sustained aerobic exercise.

Transcriptional Exercise Programme
SLU-PP-332 binds and activates all three ERR isoforms, driving a transcriptional programme that upregulates PGC-1α co-activation, increases mitochondrial density in skeletal muscle, enhances OXPHOS gene expression, and shifts substrate utilisation toward fat oxidation. Billon et al. (2024) demonstrated that ERR agonism recapitulates the acute molecular signature of aerobic exercise in muscle tissue.

Metabolic Syndrome
In diet-induced obese mouse models, SLU-PP-332 reduced body weight, improved insulin sensitivity, lowered triglycerides, and improved liver steatosis — effects consistent with ERR-mediated restoration of mitochondrial metabolism. The 2024 Billon et al. study reported significant alleviation of metabolic syndrome parameters.

Muscle Preservation
Bonanni et al. (2025) demonstrated that ERR agonism counteracts age-related muscle atrophy (sarcopenia) in preclinical models — an application of significant interest given the lack of approved pharmacological treatments for sarcopenia.

Kidney Protection
Nasri (2024) reported potential indirect renoprotective effects, likely mediated through improved metabolic control and reduced lipotoxicity rather than direct renal ERR activation.

Research Dosage Information
Preclinical compound only. No human clinical trial data. Do not attempt to obtain or self-administer.

Human pharmacokinetics, safety, and optimal dosing are entirely unknown. This compound is at an early preclinical stage.