MOTS-c
Price range: £36.99 through £67.99
MOTS-c
Metabolic — Mitochondrial Peptide MOTS-c
A mitochondria-derived peptide (MDP) encoded by the 12S rRNA gene in mitochondrial DNA — one of the first peptides discovered to be encoded by mitochondrial rather than nuclear DNA.
It acts as a metabolic regulator improving insulin sensitivity and exercise capacity, with expression declining with age.
- Origin: Mitochondrial DNA (12S rRNA)
- Key Target: AMPK pathway — metabolic regulation
- Notable finding: Plasma levels decline with age
MOTS-c
Mechanism of Action
MOTS-c translocates from mitochondria to the nucleus under metabolic stress, where it activates the AMPK pathway and regulates nuclear gene expression — a retrograde signalling mechanism unique to mitochondria-derived peptides.
Insulin Sensitivity
Promotes glucose uptake in skeletal muscle by activating AMPK and inhibiting the folate-methionine cycle, which impairs fatty acid oxidation. Mouse studies demonstrate reversal of diet-induced insulin resistance.
Exercise & Ageing
Physically active individuals show higher MOTS-c plasma levels. Exogenous MOTS-c improved exercise capacity in aged mice to levels comparable to young controls — suggesting a role as an exercise mimetic.
Research compound only — not licensed for human consumption or therapeutic use. Sold strictly for laboratory research purposes.
Vials (Peptides)
Pre-mixed Pens (Peptides)
Nasal Spray (Peptides)
Cream (Peptides)
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