5-Amino-1MQ
Price range: £42.99 through £55.99
5-Amino-1MQ
Metabolic — NNMT Inhibitor 5-Amino-1MQ
A small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme highly expressed in adipose tissue that regulates cellular energy metabolism.
By blocking NNMT, research models show increased intracellular NAD+ and SAM availability, promoting fat browning and metabolic activity in adipocytes.
- Target: NNMT (nicotinamide N-methyltransferase)
- Class: Small-molecule enzyme inhibitor
- Primary Research Focus: Adipocyte metabolism & fat loss
5-Amino-1MQ
Mechanism of Action
5-Amino-1MQ selectively inhibits NNMT, an enzyme that methylates nicotinamide using SAM (S-adenosylmethionine) as a methyl donor. By blocking this reaction, both NAD+ and SAM levels rise within the cell, altering downstream metabolic and epigenetic signalling.
Adipocyte “Browning”
NNMT is highly expressed in white adipose tissue and its activity correlates with obesity in preclinical models. Inhibiting NNMT with 5-Amino-1MQ increases cellular energy expenditure and has been associated with reduced fat mass and improved insulin sensitivity in rodent studies, without requiring caloric restriction.
NAD+ & Sirtuin Signalling
The rise in intracellular NAD+ following NNMT inhibition supports sirtuin (SIRT1) activity, linking 5-Amino-1MQ research to the broader NAD+/longevity research space alongside compounds like NAD+ and NMN.
Research compound only — not licensed for human consumption or therapeutic use. Sold strictly for laboratory research purposes.
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