GHK-CU (Pen)
GHK-CU (Pen) Price range: £44.99 through £48.99mg
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GHK-CU (Capsules)

Price range: £44.99 through £48.99mg

GHK-Cu

Gly-His-Lys · Cu²⁺
GHK-Cu is a naturally occurring copper peptide first isolated from human plasma in 1973. It upregulates over 4,000 human genes, stimulates collagen synthesis, exerts antioxidant effects, and demonstrates broad anti-inflammatory activity. A well-established topical cosmetic ingredient with growing interest in systemic applications.
Discovery
1973, Loren Pickart
Genes Modulated
>4,000
Key Metal
Copper (Cu²⁺)

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GHK-Cu

Mechanism of Action

GHK-Cu acts as a biological signal of tissue damage. Plasma levels decline from ~200 ng/mL at age 20 to ~80 ng/mL by age 60.

Gene Expression Modulation

Genome-wide microarray studies identify broad modulation of COL1A1, COL3A1, antioxidant enzymes, and anti-inflammatory pathways, appearing to reset expression toward younger phenotypes.

Copper Transport

Delivers Cu²⁺ to lysyl oxidase (collagen crosslinking) and Cu/Zn superoxide dismutase (antioxidant protection).

Exploratory reports: Small number of accounts from aesthetic and biohacking communities. Not peer-reviewed.

Volume

100mg

,

50mg

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